Synthesis, Characterization, Acute Toxicity and Investigation of the new Pyrimidine Derivative as antihyperlipidemic activity on Male Mice.

A new pyrimidine derivative was prepared by reaction of Pyridimine-4,5-diaminewith 3-Phenyl propanal in good yield. This Schiff base characterized elemental analysis, Infra-red and Proton Nuclear Magnetic Resonance (1H- NMR) spectroscopy. The toxicity the compound also assayed via determination their LD50 value using Dixon method. novel 618.75 mg/Kg BW when administered Intraperitonially. In Atorvastatin has been used as a controlled drug for treatment HFD-induced hyperlipidemia improvement drug, both atorvastatin prevented increase serum hepatic levels total cholesterol (TC), glycerides (TGs), low density lipoprotein (LDL-C), increased high-density (HDL-C) HLD-fed rats. results histopathological study sections liver groups confirmed conformity with physiological study.